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This confirmed the utility of the two established prognostic markers over TIL PD-1 expression. Several prior research have correlated PD-1/PD-L1 expression on immunohistochemistry with clinical consequence (Table 5). However, substantial inter-study variability exists among the conclusions of the research even when the comparison is confined to clear cell subtype. Among the many studies that quantified PD-1 expression, Thompson, et al., Kang, et al., and Giraldo, et al. In contrast, Shin, et al. PD-1 positivity and most cancers-specific and development-free survivals. Among the many research that quantified PD-L1 expression, Thompson, et al., Choueiri, et al., Shin, et al., and Abbas, et al. Giraldo, et al. found borderline association, while Leite, et al. 0.039) however no other prognostic components. Table 5. Studies that correlated PD-1 or PD-L1 expression in tumor cells or in immune cells with clinical final result in the descending order of publication. The inter-examine discrepancies stem from technical challenges of immunohistochemistry as well as intrinsic complexity of tumor biology.