Surgical remedy of cryptogenic neocortical epilepsy is challenging. The purpose of this research was to evaluate surgical outcomes and to identify possible prognostic factors together with the outcomes of various diagnostic instruments. Eighty-nine patients with neocortical epilepsy with normal magnetic resonance imaging (35 patients with frontal lobe epilepsy, 31 with neocortical temporal lobe epilepsy, 11 with occipital lobe epilepsy, 11 with parietal lobe epilepsy, and 1 with multifocal epilepsy) underwent invasive research and focal surgical resection. Patients were noticed for at least 2 years after surgery. The localizing values of interictal electroencephalogram (EEG), ictal scalp EEG, interictal 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), and subtraction ictal single-photon emission computed tomography had been evaluated. Seventy-one patients (80.0%) had a superb surgical end result (Engel class 1-3); Forty two patients have been seizure free. Diagnostic sensitivities of interictal EEG, ictal scalp EEG, FDG-PET, and subtraction ictal single-photon emission computed tomography were 37.1%, 70.8%, 44.3%, and 41.1%, respectively. Localization by FDG-PET and interictal EEG was correlated with a seizure-free end result. The localizing worth of FDG-PET was biggest in neocortical temporal lobe epilepsy. The focalization of ictal onset and in addition ictal onset frequency in invasive research were not associated to surgical outcome. Concordance with two or more presurgical evaluations was significantly related to a seizure-free outcome.
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